Effect of captopril on isoproterenol-induced myocardial ornithine decarboxylase activity
M Shimizu, O Irimajiri, T Nakano, T Mizokami… - Journal of molecular and …, 1991 - Elsevier
Polyamines are thought to play an essential role in cellular hypertrophy and proliferation.
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in
biosynthesis of polyamines. In this study, we evaluated the pathophysiological role of the
renin-angiotensin system in isoproterenol-induced cardiac hypertrophy, using myocardial
ODC activity as an indicator of cadiac hypertrophy. Isoproterenol caused an eight-fold
increase of myocardial ODC activity in normotensive Wistar rats within 4 h after injection …
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in
biosynthesis of polyamines. In this study, we evaluated the pathophysiological role of the
renin-angiotensin system in isoproterenol-induced cardiac hypertrophy, using myocardial
ODC activity as an indicator of cadiac hypertrophy. Isoproterenol caused an eight-fold
increase of myocardial ODC activity in normotensive Wistar rats within 4 h after injection …
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